Cardiac chamber formation

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac chamber formation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Cardiac chamber formation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LGG, show the opposite pattern, with higher activity associated with better survival.

UVM, LGG, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.862	0.465	.002	66	view →
LGG	OS	Median	All	0.886	0.742	<.001	48	view →
KIRP	OS	Tertile	All	0.869	0.969	.001	38	view →
CESC	DFS	Quartile	IV	0.906	0.333	.005	34	view →
LUSC	OS	Tertile	II,III,IV	0.655	0.807	.003	32	view →
KIRC	DFS	Quartile	All	0.919	0.828	.006	31	view →
STAD	DFS	Median	All	0.605	0.796	.011	26	view →
SCLC	DFS	Median	II,III,IV	0.205	0.819	.004	24	view →
LUAD	OS	Tertile	All	0.745	0.629	.008	19	view →
BLCA	DFS	Quartile	III,IV	0.180	0.389	.017	13	view →
DLBC	OS	Quartile	II,III,IV	0.515	0.956	.009	13	view →
PAAD	DFS	Tertile	II,III,IV	0.462	0.269	.023	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0003207–UVM (DFS)

Open the UVM breakdown →