Cardiac chamber formation

Across TCGA patient cohorts, RNA activity of the Cardiac chamber formation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX2, TNXB, and PCDH18, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac chamber formation activity versus TBX2 in CCRCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TBX2 →	+1.262	+0.611	<.001	<.001	3	7
LSCC	TNXB →	+1.073	+0.307	<.001	<.001	3	7
UCEC	PCDH18 →	+0.940	+0.432	<.001	.004	3	7
CCRCC	CASP12 →	+1.013	+0.623	<.001	<.001	3	7
CCRCC	NR2F2-AS1 →	+0.628	+0.571	.002	.003	3	7
UCEC	ADGRA2 →	+0.708	+0.495	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003207 vs TBX2 — CCRCC

Explore this scatter interactively →