Cardiac chamber morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac chamber morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB31, GPR176, and NRP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB31 grouped by Cardiac chamber morphogenesis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RAB31 →	-4.030	-1.350	<.001	<.001	3	6
BONE	GPR176 →	-2.739	-1.365	.004	<.001	3	5
BONE	NRP1 →	-4.190	-1.375	<.001	<.001	3	5
BONE	PLEKHN1 →	-1.232	-1.354	.001	<.001	3	5
BONE	SMTN →	-2.134	-1.388	<.001	<.001	3	4
OESOPHAGUS	RASSF3 →	+1.105	+1.183	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB31 by Cardiac chamber morphogenesis activity — BONE

Explore this box plot interactively →