Cardiac chamber morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac chamber morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD7, GALNT1, and GSN, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac chamber morphogenesis activity versus SMAD7 in BONE (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SMAD7 →	+1.786	+0.107	.002	.001	2	14
BONE	GALNT1 →	+1.883	+0.107	.001	<.001	3	11
BONE	GSN →	+3.703	+0.155	<.001	<.001	3	10
BONE	NRP1 →	+2.199	+0.092	.002	.004	3	10
CNS	KCNJ11 →	-0.706	-0.058	.001	.001	3	10
BONE	TGFBR2 →	+2.965	+0.121	.002	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003206 vs SMAD7 — BONE

Explore this scatter interactively →