Cardiac chamber morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac chamber morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, LMO7, and PKP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac chamber morphogenesis activity versus ANXA2 in BONE (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ANXA2 →	+1.766	+1.227	.005	.001	3	6
BONE	LMO7 →	+2.113	+1.276	.003	<.001	3	6
OESOPHAGUS	PKP2 →	+2.107	+0.822	.001	.008	3	6
BONE	ADGRG1 →	+2.960	+1.216	.002	.001	3	5
SKIN	C12orf76 →	-0.736	-1.030	.004	.004	3	5
BREAST	SLC52A3 →	+1.500	+0.504	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003206 vs ANXA2 — BONE

Explore this scatter interactively →