Cardiac chamber morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac chamber morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DSP, PKP2, and TPM1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac chamber morphogenesis activity versus DSP in PANCREAS (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DSP →	+2.023	+1.475	<.001	<.001	2	12
BLOOD_Myeloma	PKP2 →	+2.574	+1.205	.001	.003	2	11
SOFT_TISSUE	TPM1 →	+2.463	+1.356	<.001	<.001	3	9
OVARY	CDC73 →	-0.667	-0.854	<.001	.003	3	8
SOFT_TISSUE	OFD1 →	+2.146	+1.566	<.001	<.001	3	7
SKIN	PUM3 →	-0.859	-1.489	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003206 vs DSP — PANCREAS

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