Cardiac chamber development

Across TCGA cell cohorts, RNA activity of the Cardiac chamber development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROCR, PKP2, and ITPR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac chamber development activity versus PROCR in LUNG_SCLC (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PROCR →	-2.144	-0.216	.006	.004	3	5
LUNG_SCLC	PKP2 →	+2.277	+0.240	.002	.008	3	5
BLOOD_Lymphoma	ITPR1 →	-1.557	-0.357	.002	.004	3	5
LUNG_SCLC	SKI →	-0.840	-0.267	.001	<.001	3	4
LUNG_SCLC	SIX5 →	-1.475	-0.199	.003	.002	3	4
LUNG_SCLC	SMDT1 →	+0.834	+0.256	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003205 vs PROCR — LUNG_SCLC

Explore this scatter interactively →