Endocardial cushion morphogenesis

Across TCGA cell cohorts, RNA activity of the Endocardial cushion morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS13, MZT1, and RNF122, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion morphogenesis activity versus RPS13 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPS13 →	+0.546	+0.322	.006	<.001	2	4
CNS	MZT1 →	+0.424	+0.627	.007	.007	3	3
SOFT_TISSUE	RNF122 →	-1.591	-0.557	<.001	.005	3	3
SOFT_TISSUE	RAB1A →	-0.532	-0.614	<.001	.004	3	3
SKIN	NDUFB3 →	+0.265	+0.355	.009	.008	3	3
BREAST	FAM47E →	+0.904	+1.151	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003203 vs RPS13 — LUNG_NSCLC_LUAD

Explore this scatter interactively →