Epithelial to mesenchymal transition involved in endocardial cushion formation

Across TCGA patient cohorts, RNA activity of the Epithelial to mesenchymal transition involved in endocardial cushion formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKD2, BICC1, and GASK1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial to mesenchymal transition involved in endocardial cushion formation activity versus PKD2 in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PKD2 →	+0.724	+0.475	<.001	.004	3	5
HNSC	BICC1 →	+0.627	+0.514	<.001	<.001	3	4
HNSC	GASK1B →	+0.856	+0.528	<.001	<.001	3	4
HNSC	GPX8 →	+0.642	+0.436	.002	.003	2	5
BRCA	JCAD →	+0.622	+0.498	<.001	.001	3	4
HNSC	FBN1 →	+0.829	+0.521	.004	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003198 vs PKD2 — BRCA

Explore this scatter interactively →