Epithelial to mesenchymal transition involved in endocardial cushion formation

Across TCGA pan-cancer cohorts, RNA activity of the Epithelial to mesenchymal transition involved in endocardial cushion formation pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 18 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Epithelial to mesenchymal transition involved in endocardial cushion formation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCEC and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRP, COAD, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	II,III,IV	0.503	0.864	.001	60	view →
COAD	DFS	Quartile	All	0.408	0.616	.002	54	view →
MESO	OS	Median	II,III,IV	0.428	0.688	<.001	53	view →
LGG	DFS	Tertile	All	0.756	0.902	<.001	40	view →
UCEC	DFS	Median	II,III,IV	0.885	0.769	.007	30	view →
LUSC	DFS	Quartile	II,III,IV	0.624	0.801	.006	23	view →
CESC	DFS	Quartile	All	0.744	0.892	.001	22	view →
UCS	DFS	Tertile	II,III,IV	0.530	0.093	.009	12	view →
OV	DFS	Median	IV	0.341	0.553	.022	12	view →
READ	DFS	Tertile	IV	0.179	0.936	.024	9	view →
LUAD	DFS	Quartile	IV	0.435	0.910	.049	6	view →
STAD	DFS	Quartile	All	0.298	0.490	.041	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0003198–KIRP (OS)

Open the KIRP breakdown →