Epithelial to mesenchymal transition involved in endocardial cushion formation

Across TCGA cell cohorts, RNA activity of the Epithelial to mesenchymal transition involved in endocardial cushion formation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL6IP5, GINS1, and PTK7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial to mesenchymal transition involved in endocardial cushion formation activity versus ARL6IP5 in LARGE_INTESTINE (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARL6IP5 →	-0.612	-0.208	.005	.001	3	4
BLOOD_Leukemia	GINS1 →	+0.818	+0.524	.008	.006	2	4
BLOOD_Leukemia	PTK7 →	+2.765	+0.799	<.001	.003	3	3
BLOOD_Leukemia	CIT →	+0.874	+0.716	.004	.006	3	3
BLOOD_Leukemia	CEP78 →	+1.276	+0.643	<.001	.009	3	3
BLOOD_Leukemia	KIF15 →	+0.676	+0.575	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003198 vs ARL6IP5 — LARGE_INTESTINE

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