Heart valve formation

Across TCGA cell cohorts, RNA activity of the Heart valve formation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL2, SLC43A2, and VWA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LOXL2 grouped by Heart valve formation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LOXL2 →	-2.753	-1.235	.007	.006	3	5
SOFT_TISSUE	SLC43A2 →	-1.614	-1.130	.006	.003	2	6
LUNG_NSCLC_LUAD	VWA2 →	-1.278	-1.183	<.001	<.001	3	5
STOMACH	INPP1 →	+2.201	+1.625	.001	<.001	3	4
LUNG_NSCLC_LUSC	FGFBP3 →	+0.851	+1.392	.002	.001	3	4
SOFT_TISSUE	OCRL →	-0.666	-1.684	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LOXL2 by Heart valve formation activity — OESOPHAGUS

Explore this box plot interactively →