Aortic valve morphogenesis

Across TCGA patient cohorts, RNA activity of the Aortic valve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A6, CDH11, and ADAMTS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aortic valve morphogenesis activity versus SLC7A6 in OV (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC7A6 →	+0.641	+0.442	<.001	<.001	3	4
BRCA	CDH11 →	+1.221	+1.093	<.001	<.001	3	4
OV	ADAMTS2 →	+1.152	+0.333	.001	.009	3	4
BRCA	COL11A1 →	+1.488	+0.458	<.001	.004	3	4
BRCA	ST6GAL2 →	+0.842	+0.641	<.001	<.001	3	4
BRCA	C3orf80 →	+0.515	+0.572	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003180 vs SLC7A6 — OV

Explore this scatter interactively →