Aortic valve morphogenesis

Across TCGA cell cohorts, RNA activity of the Aortic valve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD81, IDNK, and PCYOX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aortic valve morphogenesis activity versus CD81 in BLOOD_Lymphoma (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CD81 →	+0.893	+0.558	.007	.006	3	4
OVARY	IDNK →	-1.370	-0.814	.003	.003	3	4
LIVER	PCYOX1 →	-1.140	-1.664	.001	<.001	3	3
BLOOD_Lymphoma	NECAB1 →	-0.459	-0.877	.006	.001	3	3
BLOOD_Lymphoma	GOLGA1 →	-0.615	-0.616	<.001	.002	3	3
BLOOD_Lymphoma	EXOC6B →	-1.002	-0.635	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003180 vs CD81 — BLOOD_Lymphoma

Explore this scatter interactively →