Heart valve morphogenesis

Across TCGA patient cohorts, RNA activity of the Heart valve morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AEBP1, CLPX, and HSPG2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart valve morphogenesis activity versus AEBP1 in BRCA (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AEBP1 →	+0.792	+0.045	<.001	<.001	3	10
OV	CLPX →	-0.333	-0.067	<.001	<.001	3	10
BRCA	HSPG2 →	+0.554	+0.059	<.001	<.001	3	10
BRCA	NEXN_S218 →	+1.363	+0.064	<.001	<.001	3	10
CCRCC	LMCD1 →	+0.732	+0.088	<.001	<.001	3	10
CCRCC	ARHGEF17 →	+0.374	+0.091	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003179 vs AEBP1 — BRCA

Explore this scatter interactively →