Heart valve morphogenesis

Across TCGA patient cohorts, RNA activity of the Heart valve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCN2, MMP19, and APLNR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart valve morphogenesis activity versus CCN2 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCN2 →	+1.223	+0.454	<.001	<.001	3	6
BRCA	MMP19 →	+0.711	+0.444	<.001	<.001	3	6
BRCA	APLNR →	+0.621	+0.473	<.001	.003	3	6
BRCA	PDGFRL →	+0.844	+0.415	<.001	<.001	3	5
OV	SYDE1 →	+0.630	+0.570	.001	.002	3	5
LSCC	MFAP2 →	+0.798	+0.303	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003179 vs CCN2 — BRCA

Explore this scatter interactively →