Heart valve morphogenesis

Across TCGA cell cohorts, RNA activity of the Heart valve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL16, HSPD1, and COA7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPL16 grouped by Heart valve morphogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MRPL16 →	+0.965	+0.900	.001	.001	3	5
LUNG_NSCLC_LUSC	HSPD1 →	+0.629	+0.953	.007	.009	2	6
KIDNEY	COA7 →	+0.819	+1.394	<.001	<.001	3	4
LARGE_INTESTINE	L1CAM →	-2.532	-0.936	.002	<.001	3	4
LARGE_INTESTINE	BCKDHA →	+0.734	+0.833	.003	.003	3	4
LUNG_NSCLC_LUSC	MTFR1 →	+0.846	+1.500	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPL16 by Heart valve morphogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →