Heart valve morphogenesis

Across TCGA cell cohorts, RNA activity of the Heart valve morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC37A4, OR10J1, and ST3GAL5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC37A4 grouped by Heart valve morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLC37A4 →	+0.142	+1.280	<.001	.004	2	4
CNS	OR10J1 →	-0.224	-0.373	<.001	.001	3	3
OESOPHAGUS	ST3GAL5 →	+0.145	+0.588	.001	<.001	3	3
URINARY_TRACT	WEE1 →	+0.577	+0.571	.002	.002	3	3
PANCREAS	DCLK1 →	-0.260	-0.943	<.001	.009	3	3
CNS	PLD4 →	+0.195	+0.571	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC37A4 by Heart valve morphogenesis activity — STOMACH

Explore this box plot interactively →