Heart valve morphogenesis

Across TCGA cell cohorts, RNA activity of the Heart valve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDF4, TERT, and ITPR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart valve morphogenesis activity versus SDF4 in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SDF4 →	-0.632	-0.817	.001	.003	3	4
BLOOD_Lymphoma	TERT →	+2.107	+0.751	.002	.001	3	4
BONE	ITPR1 →	+2.274	+1.326	<.001	.008	3	4
LUNG_SCLC	SPATA20 →	-2.001	-0.949	<.001	.002	3	4
LUNG_NSCLC_LUAD	BCL7A →	+0.630	+0.577	.005	.005	3	4
OVARY	IDNK →	-0.980	-0.744	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003179 vs SDF4 — BLOOD_Leukemia

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