Heart valve development

Across TCGA cell cohorts, RNA activity of the Heart valve development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR2F2, RBCK1, and PPM1D, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NR2F2 grouped by Heart valve development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NR2F2 →	-0.126	-0.400	<.001	.001	3	7
LUNG_NSCLC_LUAD	RBCK1 →	+0.188	+0.622	<.001	.008	3	4
LUNG_NSCLC_LUAD	PPM1D →	-0.078	-0.366	.005	.004	3	4
PANCREAS	OR5T1 →	+0.255	+0.216	.005	.002	3	4
KIDNEY	TSNARE1 →	-0.148	-1.341	.001	.003	3	4
CNS	PLCH2 →	-0.253	-0.700	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NR2F2 by Heart valve development activity — BREAST

Explore this box plot interactively →