Atrioventricular node development

Across TCGA patient cohorts, RNA activity of the Atrioventricular node development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL4A2, CYGB, and TLN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrioventricular node development activity versus COL4A2 in BRCA (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL4A2 →	+0.336	+0.041	.001	<.001	3	6
CCRCC	CYGB →	+0.443	+0.081	<.001	<.001	3	6
BRCA	TLN1 →	+0.297	+0.054	<.001	<.001	3	6
LSCC	RSU1 →	+0.308	+0.091	<.001	<.001	3	6
LUAD	DAPK3 →	+0.190	+0.074	.001	.001	3	6
LUAD	PSMD1 →	-0.116	-0.093	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003162 vs COL4A2 — BRCA

Explore this scatter interactively →