Atrioventricular node development

Across TCGA patient cohorts, RNA activity of the Atrioventricular node development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BEND3, EXOSC9, and NUP58, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrioventricular node development activity versus BEND3 in UCEC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BEND3 →	+0.396	+0.124	.004	.002	3	5
UCEC	EXOSC9 →	+0.458	+0.137	<.001	<.001	3	4
UCEC	NUP58 →	+0.384	+0.133	<.001	.001	3	4
UCEC	MAP3K2 →	+0.247	+0.109	<.001	.008	3	4
UCEC	ATP5MC1P4 →	+0.741	+0.164	.001	<.001	3	4
UCEC	AURKA →	+1.171	+0.203	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003162 vs BEND3 — UCEC

Explore this scatter interactively →