Atrioventricular node development

Across TCGA cell cohorts, RNA activity of the Atrioventricular node development pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMPR1A, GATA6, and TSSK1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMPR1A grouped by Atrioventricular node development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BMPR1A →	-0.185	-1.188	<.001	<.001	3	7
CNS	GATA6 →	-0.333	-1.128	<.001	<.001	3	6
KIDNEY	TSSK1B →	+0.380	+1.532	.001	<.001	3	5
OESOPHAGUS	ARL4D →	-0.169	-0.869	.006	.008	3	4
LUNG_SCLC	CSMD1 →	-0.391	-1.067	<.001	.005	3	4
BLOOD_Leukemia	CAMK4 →	-0.144	-0.976	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMPR1A by Atrioventricular node development activity — OVARY

Explore this box plot interactively →