Atrioventricular node development

Across TCGA cell cohorts, RNA activity of the Atrioventricular node development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTZ1, PPM1A, and SMUG1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrioventricular node development activity versus GSTZ1 in CNS (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GSTZ1 →	+1.232	+0.349	.001	.006	3	1
CNS	PPM1A →	+0.716	+0.349	.009	.006	3	1
CNS	SMUG1 →	+0.697	+0.349	.006	.006	3	1
CNS	TCP11 →	+0.186	+0.473	<.001	.007	3	1
CNS	PKDREJ →	+0.137	+0.349	.001	.006	3	1
CNS	POLN →	+0.555	+0.349	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003162 vs GSTZ1 — CNS

Explore this scatter interactively →