Atrioventricular node development

Across TCGA cell cohorts, RNA activity of the Atrioventricular node development pathway is significantly associated with the drug response of multiple features, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are GSK650394, N24798-49-A1, and TANK_1366, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSK650394 grouped by Atrioventricular node development-low versus -high activity in BREAST.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GSK650394 →	+1.335	+0.366	.007	.044	2	3
SKIN	N24798-49-A1 →	+0.193	+0.574	.043	.018	1	4
SKIN	TANK_1366 →	+0.440	+0.574	.008	.018	3	2
SKIN	Taselisib →	+0.706	+0.574	.014	.018	3	2
SKIN	Entinostat →	-0.800	-0.574	.013	.018	3	2
SKIN	LY2109761 →	-0.603	-0.574	.035	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK650394 by Atrioventricular node development activity — BREAST

Explore this box plot interactively →