Endocardium morphogenesis

Across TCGA patient cohorts, RNA activity of the Endocardium morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHAMP1_S204, BRD3, and F11R_S296, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardium morphogenesis activity versus CHAMP1_S204 in COAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CHAMP1_S204 →	+0.284	+0.050	.006	.001	3	5
CCRCC	BRD3 →	+0.227	+0.091	.002	.005	3	5
LSCC	F11R_S296 →	-0.501	-0.063	<.001	<.001	3	5
LUAD	GTF2F1_T331 →	+0.428	+0.071	.001	.001	3	5
LUAD	PROX1_S511 →	+0.775	+0.075	<.001	<.001	3	5
PDAC	SSH3_S37 →	-0.762	-0.037	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003160 vs CHAMP1_S204 — COAD

Explore this scatter interactively →