Endocardium morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Endocardium morphogenesis pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Endocardium morphogenesis pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and HNSC, show the opposite pattern, with higher activity associated with better survival.

MESO, KIRC, and LUSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.397	0.682	<.001	120	view →
KIRC	DFS	Tertile	III,IV	0.562	0.335	.001	75	view →
LUSC	OS	Median	All	0.356	0.449	.010	33	view →
SCLC	OS	Median	All	0.540	0.736	.006	27	view →
HNSC	OS	Median	IV	0.688	0.341	<.001	26	view →
THCA	OS	Median	II,III,IV	0.665	1.000	.009	20	view →
SKCM	OS	Median	III,IV	0.653	0.250	.001	19	view →
UCS	DFS	Median	IV	0.909	0.416	.008	18	view →
KIRP	DFS	Median	All	0.796	0.973	.007	18	view →
STAD	DFS	Quartile	IV	0.816	0.078	.003	16	view →
CHOL	OS	Median	All	0.362	0.861	.002	15	view →
READ	DFS	Quartile	II,III,IV	0.345	0.790	.013	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0003160–MESO (OS)

Open the MESO breakdown →