Endocardium morphogenesis

Across TCGA patient cohorts, RNA activity of the Endocardium morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PROX1_S199, PROX1_S511, and FARP1_S403, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardium morphogenesis activity versus PROX1_S199 in LSCC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PROX1_S199 →	+1.141	+0.555	<.001	<.001	3	5
OV	PROX1_S511 →	+1.409	+0.758	<.001	.001	3	4
OV	FARP1_S403 →	-2.239	-0.468	.001	<.001	3	4
UCEC	PROX1_S295 →	+1.063	+0.658	<.001	<.001	3	4
GBM	KDM3A_S463 →	+0.901	+1.042	<.001	<.001	3	3
OV	ILF3 →	+0.505	+0.591	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003160 vs PROX1_S199 — LSCC

Explore this scatter interactively →