Endocardium morphogenesis

Across TCGA cell cohorts, RNA activity of the Endocardium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARMCX5, PDGFRL, and SLC25A35, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARMCX5 grouped by Endocardium morphogenesis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ARMCX5 →	+0.660	+0.701	<.001	.006	3	4
CNS	PDGFRL →	+1.661	+0.423	<.001	.007	3	3
CNS	SLC25A35 →	+1.023	+1.081	<.001	<.001	3	3
BONE	FAM111B →	-1.373	-1.461	.005	.001	3	3
OVARY	PCLO →	+1.377	+1.178	<.001	.001	3	3
STOMACH	NXT2 →	+0.740	+1.271	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARMCX5 by Endocardium morphogenesis activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →