Endocardium morphogenesis

Across TCGA cell cohorts, RNA activity of the Endocardium morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PICK1, ABCD1, and CYP2C18, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PICK1 grouped by Endocardium morphogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PICK1 →	+0.169	+0.675	.001	.005	3	1
LARGE_INTESTINE	ABCD1 →	+0.330	+0.675	.001	.005	3	1
LARGE_INTESTINE	CYP2C18 →	+0.285	+0.573	.001	.006	3	1
LARGE_INTESTINE	UCP1 →	-0.270	-0.573	.006	.006	3	1
LARGE_INTESTINE	NEK11 →	+0.226	+0.675	.001	.005	3	1
LARGE_INTESTINE	TNNI3K →	-0.346	-0.675	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PICK1 by Endocardium morphogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →