Muscular septum morphogenesis

pathway activity — cross-omics
GO:0003150Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Muscular septum morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL12P9, KAT6A, and PMP22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCRPL12P9 →+0.763+0.926.003<.00134
PDACKAT6A →-0.739-0.248.001.00533
LSCCPMP22 →+0.587+0.860.003<.00133
LSCCTMEM204 →+0.655+0.969.001<.00133
LSCCDPT →+0.931+0.748<.001<.00133
LSCCMYLK →+0.572+0.756.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration