Determination of left/right asymmetry in lateral mesoderm

Across TCGA patient cohorts, RNA activity of the Determination of left/right asymmetry in lateral mesoderm pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCN1, KCNIP4-IT1, and VSIR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of left/right asymmetry in lateral mesoderm activity versus FCN1 in BRCA (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FCN1 →	-0.634	-0.291	<.001	<.001	3	4
UCEC	KCNIP4-IT1 →	+1.210	+0.577	.007	<.001	2	4
LSCC	VSIR →	-0.687	-0.615	<.001	<.001	3	3
LSCC	CFAP92 →	+0.362	+0.340	.009	.003	3	3
BRCA	DOK2 →	-0.673	-0.319	.005	.003	3	3
LSCC	RNF166 →	-0.336	-0.487	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003140 vs FCN1 — BRCA

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