Secondary heart field specification

Across TCGA patient cohorts, RNA activity of the Secondary heart field specification pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POLE3, RFC1_S368, and SMC4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secondary heart field specification activity versus POLE3 in LUAD (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	POLE3 →	-0.401	-0.088	<.001	<.001	3	9
PDAC	RFC1_S368 →	-0.739	-0.085	<.001	<.001	3	8
LSCC	SMC4 →	-0.481	-0.071	.001	.007	3	8
BRCA	DDX18 →	-0.353	-0.066	<.001	<.001	3	8
PDAC	DDX21_S89 →	-0.834	-0.091	<.001	<.001	3	8
UCEC	HSPA12A →	+0.606	+0.119	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003139 vs POLE3 — LUAD

Explore this scatter interactively →