Heart field specification

Across TCGA patient cohorts, RNA activity of the Heart field specification pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPA12A, DDX18, and RFC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart field specification activity versus HSPA12A in UCEC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPA12A →	+0.517	+0.074	.007	.005	3	7
BRCA	DDX18 →	-0.311	-0.047	.004	<.001	3	7
BRCA	RFC3 →	-0.301	-0.062	<.001	<.001	3	6
PDAC	SMC4 →	-0.337	-0.066	.001	.007	3	6
LUAD	CEBPZ →	-0.291	-0.058	<.001	<.001	3	6
UCEC	HMCN1 →	+0.519	+0.081	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003128 vs HSPA12A — UCEC

Explore this scatter interactively →