Regulation of systemic arterial blood pressure by endothelin

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure by endothelin pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECE1, PTN, and TACC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by endothelin activity versus ECE1 in GBM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ECE1 →	+0.593	+0.717	<.001	<.001	3	5
CCRCC	PTN →	+1.298	+0.606	.002	.004	3	3
CCRCC	TACC1 →	+0.406	+0.548	.003	<.001	3	3
CCRCC	HNRNPA1P13 →	-0.021	-0.785	.003	.002	3	3
CCRCC	ARHGAP6 →	+0.351	+0.488	.001	.006	3	3
GBM	EIF3L →	-0.297	-0.577	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003100 vs ECE1 — GBM

Explore this scatter interactively →