Renal water transport

Across TCGA patient cohorts, RNA activity of the Renal water transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AMPD2_S100, THEMIS2_T593, and TUBB6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal water transport activity versus AMPD2_S100 in LSCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AMPD2_S100 →	+0.449	+0.056	.003	.004	3	6
LUAD	THEMIS2_T593 →	+0.397	+0.064	.003	.003	3	5
OV	TUBB6 →	+0.390	+0.066	.001	<.001	3	5
LUAD	PER2_S977 →	-0.353	-0.056	.003	.009	3	5
OV	PPFIBP1 →	+0.359	+0.069	<.001	<.001	3	5
COAD	QKI →	+0.333	+0.043	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003097 vs AMPD2_S100 — LSCC

Explore this scatter interactively →