Renal sodium ion transport

Across TCGA cell cohorts, RNA activity of the Renal sodium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCC1, ZNF836, and BCAS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RCC1 grouped by Renal sodium ion transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RCC1 →	+0.494	+0.774	.004	.002	2	5
CNS	ZNF836 →	-0.429	-1.061	.001	<.001	3	4
BLOOD_Leukemia	BCAS2 →	+0.743	+1.558	<.001	<.001	3	4
LARGE_INTESTINE	DEPDC1 →	+0.809	+0.772	<.001	<.001	3	4
SKIN	SESN1 →	-1.057	-0.901	.001	.003	3	4
LIVER	SNRNP40 →	+0.734	+1.542	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RCC1 by Renal sodium ion transport activity — CNS

Explore this box plot interactively →