Regulation of glomerular filtration

Across TCGA patient cohorts, RNA activity of the Regulation of glomerular filtration pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGM5, RASGRF2, and GAS6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glomerular filtration activity versus PGM5 in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PGM5 →	+0.861	+0.603	<.001	<.001	3	5
BRCA	RASGRF2 →	+0.789	+0.775	.001	.003	3	4
CCRCC	GAS6 →	+0.598	+0.456	<.001	.007	3	4
BRCA	FLRT2 →	+0.629	+1.059	.002	<.001	3	4
CCRCC	NOMO2 →	-0.553	-0.799	<.001	<.001	3	4
BRCA	TSHZ3 →	+0.427	+0.549	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003093 vs PGM5 — BRCA

Explore this scatter interactively →