Renal water homeostasis

Across TCGA patient cohorts, RNA activity of the Renal water homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NES, NES_S768, and NID2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal water homeostasis activity versus NES in HNSC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NES →	+0.618	+0.055	.002	.005	3	6
OV	NES_S768 →	+0.621	+0.061	<.001	.001	3	6
OV	NID2 →	+0.550	+0.073	<.001	<.001	3	6
LSCC	RFC4 →	-0.345	-0.055	.001	<.001	3	5
LSCC	VIM →	+0.327	+0.052	<.001	<.001	3	5
LSCC	CHTF18_S871 →	-0.550	-0.066	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003091 vs NES — HNSC

Explore this scatter interactively →