Positive regulation of systemic arterial blood pressure

Across TCGA cell cohorts, RNA activity of the Positive regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZDHHC6, KIF12, and DUSP14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of systemic arterial blood pressure activity versus ZDHHC6 in BREAST (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZDHHC6 →	-0.960	-1.535	<.001	<.001	3	4
LARGE_INTESTINE	KIF12 →	-2.191	-1.379	<.001	<.001	3	4
LARGE_INTESTINE	DUSP14 →	+1.150	+1.292	<.001	<.001	3	4
BREAST	ACOT8 →	+1.548	+1.544	<.001	<.001	3	4
BREAST	ELMO2 →	+0.910	+1.240	.001	<.001	3	4
SOFT_TISSUE	PRR22 →	-1.322	-1.686	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003084 vs ZDHHC6 — BREAST

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