Regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COIL_T303, ESF1, and MPHOSPH10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure activity versus COIL_T303 in OV (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COIL_T303 →	-1.308	-0.034	<.001	<.001	3	9
OV	ESF1 →	-0.541	-0.037	<.001	<.001	3	9
OV	MPHOSPH10 →	-0.390	-0.029	.003	.001	3	9
LSCC	RRP36_S73 →	-0.846	-0.047	<.001	<.001	3	9
HNSC	RFC4 →	-0.474	-0.048	<.001	<.001	3	8
GBM	RNPS1 →	-0.279	-0.048	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003073 vs COIL_T303 — OV

Explore this scatter interactively →