Regulation of systemic arterial blood pressure

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADM5, JPH2, and CTSZ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure activity versus ADM5 in LUNG_SCLC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ADM5 →	-0.751	-0.233	.001	.006	2	6
CNS	JPH2 →	+2.435	+0.283	<.001	<.001	3	5
BLOOD_Leukemia	CTSZ →	+2.144	+0.258	.002	.005	3	5
BLOOD_Leukemia	LAMP1 →	+0.850	+0.381	<.001	.004	3	5
BLOOD_Leukemia	LPCAT2 →	+3.348	+0.294	<.001	<.001	3	4
PANCREAS	ZNF891 →	-0.618	-0.327	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003073 vs ADM5 — LUNG_SCLC

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