Renal system process involved in regulation of systemic arterial blood pressure

Across TCGA cell cohorts, RNA activity of the Renal system process involved in regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPARGC1B, VIRMA, and TSNARE1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPARGC1B grouped by Renal system process involved in regulation of systemic arterial blood pressure-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PPARGC1B →	+0.733	+1.193	.006	.001	3	7
LUNG_SCLC	VIRMA →	-0.748	-1.402	.002	.001	3	5
BLOOD_Leukemia	TSNARE1 →	-2.322	-1.331	.006	.003	3	5
LIVER	COL26A1 →	+3.669	+1.762	.003	<.001	3	4
LIVER	MOB3A →	-1.568	-1.790	<.001	<.001	3	4
LIVER	CFLAR →	-1.209	-1.324	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPARGC1B by Renal system process involved in regulation of systemic arterial blood pressure activity — CNS

Explore this box plot interactively →