Regulation of the force of heart contraction by chemical signal

pathway activity — cross-omics
GO:0003057Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of the force of heart contraction by chemical signal pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASZ1, AHNAK2_S2666, and UNC13D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVCASZ1 →-1.290-0.156.007.00336
OVAHNAK2_S2666 →+0.960+0.111.002.00936
LUADUNC13D →+0.282+0.078.001.00135
GBMEHBP1L1 →+0.405+0.077<.001<.00135
GBMAHNAK2_S260 →+1.245+0.131<.001<.00135
BRCAPPP1R18_S195 →+0.380+0.071.003<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration