Vascular process in circulatory system

Across TCGA cell cohorts, RNA activity of the Vascular process in circulatory system pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBED8, USP11, and PIMREG, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular process in circulatory system activity versus ZBED8 in OESOPHAGUS (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZBED8 →	-0.913	-0.058	.001	.001	3	11
URINARY_TRACT	USP11 →	-0.991	-0.037	<.001	<.001	3	10
BLOOD_Lymphoma	PIMREG →	-1.521	-0.027	<.001	<.001	3	10
LARGE_INTESTINE	HECTD2 →	-0.963	-0.040	.001	<.001	3	10
LUNG_NSCLC_LUSC	SPINDOC →	-0.844	-0.041	.001	.004	3	10
LIVER	SPEG →	-3.027	-0.050	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003018 vs ZBED8 — OESOPHAGUS

Explore this scatter interactively →