Renal system process

Across TCGA patient cohorts, RNA activity of the Renal system process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLU, LTBP2, and NDNF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal system process activity versus CLU in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLU →	+1.044	+0.130	<.001	.001	3	5
LSCC	LTBP2 →	+0.654	+0.147	<.001	.003	3	5
LSCC	NDNF →	+1.410	+0.166	<.001	<.001	3	5
LSCC	CAPN3 →	+0.429	+0.158	.003	.006	3	5
OV	FBXL12 →	+0.592	+0.195	.001	<.001	3	4
LSCC	NFATC2 →	+0.531	+0.138	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003014 vs CLU — BRCA

Explore this scatter interactively →