Skeletal muscle contraction

Across TCGA patient cohorts, RNA activity of the Skeletal muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VIM, MAP7, and SRSF5_S250, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle contraction activity versus VIM in BRCA (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VIM →	+0.388	+0.022	.001	.004	3	6
CCRCC	MAP7 →	-0.408	-0.037	.004	.002	3	6
HNSC	SRSF5_S250 →	-0.380	-0.146	.004	<.001	3	5
HNSC	SYNPO2_S930 →	+1.089	+0.143	<.001	<.001	3	5
BRCA	VIM_S412 →	+0.747	+0.024	.001	.003	3	5
LSCC	VIM_S73 →	+0.339	+0.021	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003009 vs VIM — BRCA

Explore this scatter interactively →