Lipid hydroxylation

Across TCGA patient cohorts, RNA activity of the Lipid hydroxylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CMPK1, PLEKHA6, and ILK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid hydroxylation activity versus CMPK1 in HNSC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CMPK1 →	+0.241	+0.467	.001	<.001	3	6
LUAD	PLEKHA6 →	+0.442	+0.387	.002	.003	3	5
GBM	ILK →	-0.308	-0.673	<.001	<.001	3	5
LUAD	BCAS1 →	+1.246	+0.445	.001	.005	3	4
LUAD	CHCHD3 →	+0.132	+0.411	.006	.001	3	4
PDAC	STUB1 →	+0.140	+0.076	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002933 vs CMPK1 — HNSC

Explore this scatter interactively →