Negative regulation of humoral immune response mediated by circulating immunoglobulin

Across TCGA patient cohorts, RNA activity of the Negative regulation of humoral immune response mediated by circulating immunoglobulin pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S648, BTK, and CCDC102A_S12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of humoral immune response mediated by circulating immunoglobulin activity versus TNS2_S648 in PDAC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TNS2_S648 →	+0.405	+0.062	.003	.002	3	5
LSCC	BTK →	+0.409	+0.086	<.001	<.001	3	5
UCEC	CCDC102A_S12 →	+0.440	+0.086	.003	<.001	3	5
LSCC	GMPPB →	+0.308	+0.100	.001	<.001	3	5
GBM	SEPTIN1_S315 →	+0.738	+0.075	.007	.003	3	5
LSCC	TNS2_S120 →	+0.655	+0.094	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002924 vs TNS2_S648 — PDAC

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