Negative regulation of humoral immune response mediated by circulating immunoglobulin

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of humoral immune response mediated by circulating immunoglobulin pathway is associated with patient survival in 15 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher Negative regulation of humoral immune response mediated by circulating immunoglobulin pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

LUSC, LUAD, and PAAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	II,III,IV	0.814	0.630	.001	59	view →
LUAD	DFS	Tertile	All	0.788	0.592	.003	56	view →
PAAD	DFS	Tertile	All	0.443	0.188	.001	33	view →
LIHC	OS	Quartile	All	0.872	0.547	.004	19	view →
SCLC	OS	Tertile	II,III,IV	0.267	0.702	.002	18	view →
STAD	OS	Median	III,IV	0.698	0.295	.005	14	view →
COAD	OS	Tertile	III,IV	0.652	0.916	.007	14	view →
ACC	OS	Quartile	IV	0.844	0.383	.006	11	view →
SKCM	OS	Quartile	All	0.527	0.339	.005	10	view →
BLCA	OS	Quartile	II,III,IV	0.802	0.669	.018	9	view →
MESO	OS	Quartile	All	0.391	0.247	.026	9	view →
KICH	OS	Median	II,III,IV	0.860	1.000	.028	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

GO:0002924–LUSC (DFS)

Open the LUSC breakdown →